Publications

Piantadosi PT, Princz-Lebel O, Skirzewski M, Dumont JR, Palmer D, Memar S, Saksida LS, Prado VF, Prado MAM, Bussey TJ, Holmes A. Integrating optical neuroscience tools into touchscreen operant systems. Nature Protocols, 20, 2418-2452. doi: 10.1038/s41596-025-01143-x.
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Dumont JR, Sheppard PAS, Fodor C, Coto MA, Yang S, Saito T, Saido TC, Rylett RJ, Prado MAM, Bussey TJ, Saksida LM, Prado VF. Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy. Genes Brain Behaviour. 24(3):e70024. doi: 10.1111/gbb.70024.
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Hersey AY, Sheppard PAS, Kim R, Pham TNM, López-Cruz L, Bussey TJ, Saksida LM. Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber. Scientific Reports, 15(1):13689. doi: 10.1038/s41598-025-98303-6.
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Dexter TD, Palmer D, Schormans AL, Hamidullah S, Machado MMF, Allman BL, Bussey TJ, Saksida LM. Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice. Molecular Psychiatry, 2025. doi: 10.1038/s41380-025-03386-2.
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Cho, S.Y., Kim, E.W., Park, S.J., Phillips, B.U., Jeong, J., Kim, H., Heath, C.J., Kim, D., Jang, Y., Lopez-Cruz, L., Saksida, L.M., Bussey, T.J., Lee, D.Y., & Kim, E. (2024) Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice. Translational Psychiatry, 14: 34. doi: 10.1038/s41398-024-02755-9.
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Foerster, S., Floriddia, E.M., van Bruggen, D., Kukanja, P., Herve, B., Cheng, S., Kim, E., Phillips, B.U., Heath, C.J., Tripathi, R.B., Call, C., Bartels, T., Ridley, K., Neumann, B., Lopez-Cruz, L., Crawford, A.H., Lynch, C.J., Serrano, M., Saksida, L., Rowitch, D.H., Mobius, W., Nave, K.-A., Rasband, M.N., Bergles, D.E., Kessaris, N., Richadson, W.D., Bussey, T.J., Zhao, C., Castelo-Branco, G., & Franklin, R.J.M. (2024) Developmental origin of oligodendrocytes determines their function in the adult brain. Nature Neuroscience. doi: 10.1038/s41593-024-01666-8.
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Lopez-Cruz, L., Phillips, B.U., Hailwood, J.M., Saksida, L.M., Heath, C.J. & Bussey, T.J. (2024) Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task. Neuropharmacology, 49: 422-432. doi: 10.1038/s41386-023-01707-z.
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Sheppard, P.A.S., Oomen, C.A., Bussey, T.J., & Saksida, L.M. (2024) The Granular Retrosplenial Cortex Is Necessary in Male Rats for Object-Location Associative Learning and Memory, But Not Spatial Working Memory or Visual Discrimination and Reversal, in the Touchscreen Operant Chamber. eNeuro, : 11. doi: 10.1523/ENEURO.0120-24.2024.
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German-Castelan, L., Shanks, H.R.C., Gros, R., Saito, T., Saido, T.C., Saksida, L.M., Bussey, T.J., Prado, M.A.M,  Schmitz, T.W., Prado, V.F, & the Australian Imaging Biomarkers and Lifestyle flagship study of aging. (2023) Sex-dependent cholinergic effects on amyloid pathology: A translational study. Alzheimer’s & Dementia, 20: 755-1477. doi: 10.1002/alz.13481.
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Memar, S., Jiang, E., Prado, V.F., Saksida, L.M., Bussey, T.J., & Prado, M.A.M. (2023) Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes+. Sci Data, 10: 210. doi: 10.1038/s41597-023-02106-1.
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Tullo, S., Miranda, A.S., del Cid-Pellitero, E., Lim, M.P., Gallino, D., Attaran, A., Patel, R., Novikov, V., Park, M., Beraldo, F.H., Luo, W., Shlaifer, I., Durcan, T.M., Bussey, T.J., Saksida, L.M.,  Fon, E.A., Prado, V.F., Prado, M.A.M, & Chakravarty, M.M. (2023) Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms. Journal of Neurochemistry. doi: 10.1111/jnc.15967.
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Kljakic, O., Janíčková, H., Skirzewski, M., Reichelt, A., Memar, S., El Mestikawy, S., Li, Y., Saksida, L.M., Bussey, T.J., Prado, V.F., & Prado, M.A.M. (2022) Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons. FASEB J., 36(2):e22135. doi: 10.1096/fj.202101425R.
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Lackie, R.E., de Miranda, A.S., Lim, M.P., Novikov, V., Madner, N., Karunatilleke, N.C., Rutledge, B.S., Tullo, S., Brickenden, A., Maitland, M.E.R., Greenberg, D., Gallino, D., Luo, W., Ataram, A., Shlafer, I., Del Cid Pelliter, E., Schild-Poulter, C., Durcan, T.M., Fon, E.A., Duennwald, M., Beraldo, F.H., Chakravarty, M.M., Bussey, T.J., Saksida, L.M., Soreq, H., Choy, W-Y., Prado, V.F., Prado, M.A.M. (2022) Stress-inducible phosphopretein 1 (HOP/STI1/STIP1) regulates the spreading, aggregation, and toxicity of α-synuclein in vivo. Acta Neurophathologica. 144(5):881-910. doi: 10.1007/s00401-022002491-8.
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Muratoglu, S.C., Charette, M.F., Galis, Z.S., Greenstein, A.S., Daugherty, A., Joutel, A., Kozel, B.A., Wilcock, D.M., Collins, E.C., Sorond, F.A., Howell, G.R., Hyacinth, H.I., Lloyd, K.K.C., Stenmark, K.R., Boehm, M., Kahn, M.L., Corriveau, R., Wells, S., Bussey, T.J., Sukoff Rizzo, S.J., & Iruela-Arispe, M.L. (2022) Perspectives on Cognitive Phenotypes and Models of Vascular Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 0:10.. doi: 10.1161/ATVBAHA.122.317395
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Skirzewski, M., Molotchnikoff, S., Hernandez, L.F.,  & Maya-Vetencourt, J.F. (2022) Multisensory integration: Is medial prefrontal cortex signaling relevant for the treatment of higher-order visual dysfunctions? Front. Mol. Neurosci., 14: 806376. doi: 10.3389/fnmol.2021.806376.
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Skirzewski, M., Princz-Lebel, O., German-Castelan, L., Crooks, A.M., Kyungwook, K., Henke Tarnow, S., Reichelt, A., Memar, S., Palmer, D., Li, Y., Rylett, R.J., Saksida, L.M., Prado, V.F., Prado, M.A.M., & Bussey, T.J. (2022) Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues. Nature Communications, 13: 7924. doi: 10.1038/s41467-022-35601-x.
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Sullivan, J.A. (2022) Novel Tool Development and the Dynamics of Control: The Rodent Touchscreen Operant Chamber as a Case Study. Philosophy of Science , Accepted manuscript , pp. 1 – 19. doi: 10.1017/psa.2022.63.
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Anderson, K.R., Harris, J.A., Ng, L., Prins, P., Memar, S., Ljungquist, B., Furth, D., Williams, R.W., Ascoli, G.A., & Dumitriu, D. (2021) Highlights from the era of open source web-based tools. Journal of Neuroscience, 41(5): 927-936. doi: 10.1523/JNEUROSCI.1657-20.2020
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Janickova, H., Kljakic, O., Robbins, T.W., Saksida, L.M., Bussey, T.J., Prado, V.F. & Prado, M.A.M. (2021) Evaluating Sequential Response Learning in the Rodent Operant Touchscreen. Curr. Protoc., 1(10):e268. doi: 10.1002/cpz1.268
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Palmer, D., Dumont, J.R., Dexter, D.T., Prado, M.A.M., Finger, E.C., Bussey, T.J., & Saksida, L.M. (2021) Touchscreen Cognitive testing: Cross-Species Translation and Co-Clinical Trials in Neurodegenerative Disease. Neurobiology of Learning and Memory,182:107443. doi: 10.1016/j.nlm.2021.107443.
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Reichelt, A.C., Kramar, C.P., Ghosh-Swaby, O.R. Sheppard, P.A.S., Kent, B.A., Bekinschtein, P., Bussey, T.J., & Saksida, L.M. (2021) The spontaneous location recognition task for assessing spatial pattern separation and memory across a delay in rats and mice. Nature Protocols. doi: 10.1038/s41596-021-00627-w
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Reichelt, A.C., Lemieux, C.A., Princz-Lebel, O., Singh, A., Bussey, T.J., & Saksida, L.M. (2021) Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. Scientific Reports, 11(1):5593. doi: 10.1038/s41598-021-85092-x
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Sullivan, J.A., Dumont, J.R., Memar, S., Skirzewski, M., Wan, J., Mofrad, M.H., Ansari, H.Z., Li, Y., Muller, L., Prado, V.F., Prado, M.A.M., Saksida, L.M., & Bussey, T.J. (2021) New frontiers in translational research: Touchscreens, open science, and The Mouse Translational Research Accelerator Platform (MouseTRAP).  Genes Brains and Behavior. (2021) 20(1):e12705. doi: 10.1111/gbb.12705 
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Xu, X., Cowan, M., Beraldo, F., Schranz, A., McCunn, P., Geremia, N., Brown, Z., Nygard, K.L., Khazaee, R., Lu, L., Liu, X., Strong, M.J., Dekaban, G.A., Menon, R., Bartha, R., Daley, M., Mao, H., Prado, V., Prado, M.A.M., Saksida, L.M., Bussey, T.J.,  & Brown, A. (2021) Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes. Acta Neuropathologica Communications, 9(1):60 doi: 10.1186/s40478-021-01161-2 
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Binning, W., Hogan-Cann, A.E., Yae Sakae, D., Maksoud, M., Ostapchenko, V., Al-Onaizi, M., Matovic, S., Lu, W.Y., Prado, M.A.M., Inoue, W., & Prado, V.F. (2020). Chronic hM3Dq signaling in microglia ameliorate neuroinflammation in male mice. Brain, Behavior, and Immunity, 88: 791-801. doi: 10.1016/j.bbi.2020.05.041
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Bodden, C., Hannan, A.J. and Reichelt, A.C. (2020).  Diet-induced modification of the sperm epigenome programs metabolism and behaviour.  Trends in Endocrinology & Metabolism, 31: 131-149. doi: 10.1016/j.tem.2019.10.005
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Dumont, J.R., Salewski, R., and Beraldo, F. (2020). Critical mass: The rise of a touchscreen techology community for rodent cognitive testing. Genes, Brain, and Behaviour, e12650. doi: 10.1111/gbb.12650
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Jing, M., Yuexuan, L., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J., Trinh, S., Wu, R., Zhang, S., Pan, S., Hires, S.A., Xu, M., Li, H., Saksida, L.M., Prado, V.F., Bussey, T.J., Prado, M.A.M., Chen, L., & Cheng, H., Li, Y. (2020). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, 17(11):1139-1146. doi: 10.1038/s41592-020-0953-2 
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Lackie, R.E., Razzaq, A.R., Farhan, S.M.K., Qiu, L.R., Moshitzky, G., Beraldo, F.H., Lopes, M.H., Maciejewski, A., Gros, R., Fan, J., Choy, W,-Y., Greenberg, D.S., Martins, V.R., Duennwald, M.L., Lerch, J.P., Soreq, H., Prado, V.F. & Prado, M.A.M. (2020). Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1. Journal of Neurochemistry, 153: 727-758. doi: 10.1111/jnc.14882
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Lowe, C.J., Morton, J.B., & Reichelt, A.C. (2020). Adolescent obesity and dietary decision making – a brain-health perspective. Lancet Child Adolescent health, 4: 388-396. doi: 10.1016/S2352-4642(19)30404-3
[Pubmed]

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S , Furlanis E, Gomez AM, Hoshina N, HuangW-H, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Ling-Lin Pai E, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, & Craig AM. (2020). Optimizing nervous system-specific gene targeting with Cre driver lines:  Prevalence of germline recombination and influencing factors. Neuron, 106:37-65.e5. doi: 10.1016/j.neuron.2020.01.008
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Martin-Kenny, N. & Berube, N.G. (2020). Effects of postnatal Atrx conditional knockout in neurons on autism-like behaviours in male and female mice. Journal of Neurodevelopmental Disorders 12:17. doi: 10.1101/2020.02.05.936260
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Tamming, R.J., Dumeaux, V., Jiang, Y., Shafiq, S., Langlois, L., Ellegood, J., Qiu, L.R., Lerch, J.P., & Berube, N.G. (2020). Atrx deletion in neurons leads to sexually dimorphic dysregulation of miR-137 and spatial learning and memory deficits.  Cell Reports, 31: 107838. doi: 10.1016/j.celrep.2020.107838
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Beraldo, F.H., Palmer, D., Memar, S., Wasserman, D.I., Lee, W.-J.V., Liang, S., Creighton, S.D., Kolisnyk, B., Cowan, M.F., Mels, J., Masood, T.S., Fodor, C., Al-Onaizi, M.A., Bartha, R., Gee, T., Saksida, L.M., Bussey, T.J., Strother, S.S., Prado, V.F., Winters, B.D., Prado, M.A.M. (2019). Mousebytes, an open-acess high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.  Cell Reports, 31: 107838. doi: 10.7554/eLife.49630
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Frame, A.K., Lone, A., Harris, R., & Cumming RC. (2019). Simple protocol for distinguishing drug-induced effects on spatial memory acquisition, consolidation, and retrieval in mice using the Morris water maze. Bio-protocol. 9(19) Doi: 10.21769/BioProtoc.3376
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Janickova, H., Kljakic, O., Rosborough, K., Raulic, S., Matovic, S., Gros, R., Saksida, L.M., Bussey, T.J., Inoue, W., Prado, V.F., Prado, M.A.M. (2019). Selective decrease of cholinergic signaling from pedunculopontine and laterodorsal tegmental nuclei has little impact on cognition, but markedly increases susceptibility to stress. The FASEB Journal doi: 10.1096/fj.201802108R
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Lehner, K.R., Silverman, H., Adorissio, M., Roy, A., Al-Onaizi, M., Levine, Y., Olofsson, P.S., Chavan, S.S., Gros, R., Nathanson, N., Al-abed, Y., Metz, C.N., Prado, V.F., Prado, M.A.M., Tracey, K., and Pavlov, V.A. (2019). Forebrain cholinergic signaling regulates innate immune responses and inflammation. Front. Immunol. doi: 10.3389/fimmu.2019.00585
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Leite Schetino, L.P., de Castro Fonseca, M., Gomes, M.P.S.M., Valadão, P.A.C., de Camargo, W.L., Rodrigues, H.A., Andrade, J.N., Arantes-Costa, F.M., Naves, L.A., Prado, C.M., Prado, V.F., Prado, M.A.M., and Guatimosim, C. Evaluation of the neuromuscular junction in a middle-aged mouse model of congenital myasthenic syndrome. Muscle & Nerve. 60: 790-800 Doi: 10.1002/mus.26710
[Pubmed]

Lourenco, M.V., Frozza, R.L., de Freitas, G.B., Zhang, H., Kincheski, G.C. et al. (2019). Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nat. Med. 25: 165-175. doi: 10.1038/s41591-018-0275-4
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Ostapchenko, V.G., Snir, J., Suchy, M., Fan, J., Cobb, M.R., Chronik, B.A., Kovacs, M., Prado, V.F., Hudson, R.H.E., Pasternak, S.H., Prado, M.A.M & Bartha, R. (2019). Detection of active Caspase-3 in mouse models of stroke and Alzheimer’s disease with a novel dual positron emission tomography/fluorescent tracer [68Ga]Ga-TC3-OGDOTA. Contrast Media & Molecular Imaging. 2019:6403274. doi: 10.1155/2019/6403274
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Reichelt, A.C., Gibson, G.D., Abbott, K.N. & Hare, D.J. (2019). A high-fat high-sugar diet in adolescent rats impairs  social memory and alters chemical markers characteristic of atypical neuroplasticity and GABAergic neurodevelopment in the medial prefrontal cortex. Food and Function, 10, 1985 . doi: 10.1039/C8FO02118J
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Reichelt, A.C., Hare, D.J., Bussey, T.J. & Saksida, L.M. (2019). Perineuronal nets: Plasticity, protection and therapeutic potential. Trends in Neurosciences, 42: 458-470. doi: 10.1016/j.tins.2019.04.003
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Santana, F.P.R., Pinheiro, N.M., Bittencourt-Mernak, M.I., Perini, A., Yoshizaki, K., Macchione, M., Saldiva, P.H.N., Martins, M.A., Tibério, I.F.L.C., Prado, M.A.M., Prado, V.F., & Prado, C.M. (2019). Vesicular acetlcholine transport deficiency potentiates some inflammatory responses induced by diesel exhaust particles. Ecotoxicol Environ Saf. 167:494-504. Doi: 10.1016/j.ecoenv.2018.10.005
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Zmavc, K. D., & Kramar, C. P. (2019). Measuring mood in rodents:  From mazes to touchscreens. University of Western Ontario Medical Journal, 87(S1), 4-7. doi: 10.5206/uwomj.v87iS1.4878
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Beraldo, F.H., Ostapchenko, V.G., Xu, J.Z., Di Guglielmo, G.M., Fan, J., Nicholls, P.J., Caron, M.G., Prado, V.F., & Prado, M,A,M. (2018). Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex. J Neurochem. 145(1):68-79. doi: 10.1111/jnc.14281
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White, M.A*., Kim, E*., Duffy, A., Adalbert, R., Phillips, B.U., Peter, O.M., Stephenson, J., Yang, S., Massenzio, F., Lin, Z., Andrews, S., Segonds-Pichon, A., Metterville, J., Saksida L.M., Mead, R., Ribchester, R.R., Barhomi, Y., Serre, T., Coleman, M.P., Fallon, J., Bussey T.J., Brown Jr, R.H., & Sreedharan, J. (2018). TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD. Nature Neuroscience 2018 vol 21, 552-563. doi: 10.1038/s41593-018-0113-5
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Janickova, H., Prado, V.F., Prado, M.A.M., El Mestikawy, S., & Bernard, V. (2017). Vesicular acetylcholine transporter (VAChT) over-expression induces major modifications of striatal cholinergic interneuron morphology and function. J Neurochem. 142(6):857-875 doi: 10.1111/jnc.14105
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Kljakic, O., Janickova, H., Prado, V.F., & Prado, M.A.M. (2017). Cholinergic/glutamatergic co-transmission in striatal cholinergic interneurons: New mechanisms regulating striatal computation. J Neurochem. Suppl 2:90-102. doi: 10.1111/jnc.14003
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